Clonadine use is on the FAA's unacceptable list because of its centrally acting issues (e.g. drowsiness, mental confusion). Fortunately there are better antihypertensives that aren't. Caution, one class (diuretics) may exacerbate a hydration problem. As far as statins go (e.g., lipitor), the frequency of muscle spasms reported in over 16,000 patients is 3.6% for lipitor users; but still 3.0% in the placebo arm. So, taking nothing causes nearly as much cramping as taking lipitor. The most frequent side-effect is nasopharyngitis (a cold by any other name) at 8.3% vs 8.2% placebo.
Tonic water: Reported to help some, but is carbonated (bad) and many brands contain sugar.
Coconut water: Hydrating, contains high content of most of the good electrolytes and is low in sugar.
Pickle juice and Vinegar: I've refereed many Hispanic soccer players that swear drinking pickle juice provides almost instant relief of cramps; Vinegar (acetic acid) alone (also in PJ) may relieve cramping. Published results (see below) suggest the positive effects are likely not due to electrolyte/hydration rebalancing, but triggers a neurologic modulation of neuromuscular units (alpha-motor neurons).
Too much water may be bad? Yes, it can be a problem as being overhydrated can dilute your circulating electrolytes (damned if you do, damned if you don't). If you talk with ER physicians/nurses, they will tell you that patients admitted with yet-undiagnosed conditions will improve once a saline IV drip is running.
Compression stockings: Anecdotal findings that they are prophylactic to cramps. They work for me on long intercontinental flights. An ongoing clinical trial (many of which you can sign up for as a test subject) is exploring the value of compression stockings and magnesium supplements on leg cramps. Heat increases circulation and I've used chemical heating pads on my calf (slower activation time at high altitudes). A virtually guaranteed trick for immediate relief of calf cramping is to have someone push your toe hard toward the knee (dorsiflexion). It's difficult to do this alone, so I bring a stiff piece of rope that I can loop around my toe and pull. Helps with exercising your cold feet, too.
A big group to choose from: Widespread use of liquids by athletes purported to work against cramps- "dill and sweet pickle juices, yellow mustard, sweet relish, apple cider vinegar, Hot Shot, PJ Shot, PJ Sport, E-Lyte Sport, Powerade, Gatorade, Smartwater, and Propel+ among others."
Phyllis
https://pubmed.ncbi.nlm.nih.gov/32459412/
Quantitative Analysis of the Acetic Acid Content in Substances Used by Athletes for the Possible Prevention and Alleviation of Exercise-Associated Muscle Cramps - National Institutes of Health
Marosek, SEH, Antharam, V, and Dowlatshahi, K. Quantitative analysis of the acetic acid content in substances used by athletes for the possible prevention and alleviation of exercise-associated muscle cramps. J Strength Cond Res 34(6): 1539-1546, 2020-Athletes regularly consume commercially availabl …
pubmed.ncbi.nlm.nih.gov
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8628416/
Prevention of leg cramps by using compression stockings or magnesium supplements in the 50–84 age group: study protocol for a randomised controlled trial
Leg cramps are painful sensations of tightening in the muscles of the legs that commonly appear during the night and are often associated with secondary insomnia. They are common especially in older age. There is no evidence that any method of prevention ...
www.ncbi.nlm.nih.gov
https://www.faa.gov/about/office_org/headquarters_offices/avs/offices/aam/ame/guide/pharm/antihyp/
https://www.visitcompletecare.com/blog/urgent-care-iv-fluids-for-dehydration/
Emergency Room IV Fluids for Dehydration - Complete Care
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Guide for Aviation Medical Examiners - Federal Aviation Administration
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