I have two pairs of Middleburn RS7 cranks installed on bikes, both using their Duo chainrings (42/29 rings on one and 38/27 on the other), and using Phil Wood 103mm bottom brackets gives me a 45mm chainline. I also have one of their RO2 cranksets on a bike with press-fit BB, and I have their Incy spider on that, which uses 110BCD for the outer ring and 58 BCD for the inner, so you can setup a combination such as 40/22. You can also get spiders for the Middleburn cranks to set them up as 130/74, 110/74, 94/58, 104/64, etc.
I haven't measured the Q for any of the Middleburn cranks, but I ride very much heels in/toes out, and so I like cranks that flare out from BB spindle to pedal eye, or I have problems with the inside of my heel hitting the crank as I pedal. I have one pair of Shimano Deore touring cranks from the early 1980s, where the cranks don't flare out at all but are completely parallel to the centreline of the bike, and I had to fit pedal spindles
10mm longer
than standard to avoid heel strike on the cranks.
Nick Payne