1. Welcome to the esoteric and exotic world of fixed gear bike gearing.
2. Multiplicity in the rear is always better than multiplicity at the front. Hermeneutic: a. A single tooth's difference in the rear makes a much bigger gearing jump than a single tooth's difference in the front. b. It's much easier to swap the chain from a cog to an adjacent cog, while you are squatting behind the bike manipulating the QR or your box wrench with one hand, than to do this from one chainring to another.
3. You must strike a careful balance between doing what you can with what you have, and selecting the gearing that best suits you and your riding needs. Hermeneutic: a. Decide where the bike will most be ridden: Kansas or Boulder? Smooth pavement or 2" deep sand? Unladen or pulling a child trailer? b. Choose your gearing strategy. Hermeneutic: i. Do you stop and swap cogs at the slightest rise? Or do you hate stopping and prefer to grind up hills and against winds? ii. Do you prefer to twiddle on flats in order to have an easier gear for climbs? Do you have a freewheel for downhills? c. Taking this into account, choose a comfortable cruising gear, one suited for flat land speed and still winds. d. Choose a lower gear that will nicely serve when (i) you are feeling weak and the wind is strong; (ii) you have an exceptionally long hill that can't simply be walked (my cutoff for taking the trouble to swap cogs is about 1/2 mile. I can generally go at least 1/4 mile up even a 10%+ grade, and I don't mind walking 1/4 mile).
Commentary: my own experience started with the worry about hills: I need a low gear to climb. So for road riding I started with a 63" gear. Too damned low; nothing more futile and exasperating than flailing away hopelessly on a flat with a tailwind in too low a gear. Easier to suffer a bit on the climbs. I moved to ~67-68", then to 70" for a bike that sees loads and that has fender flaps and bags to catch the wind; 75-76" for a gofast. These gears have served me well in rolling, windy terrain for 17+ years. I go down 2 teeth on the flip cogs -- 63" and 67" respectively -- for longer climbs and strong headwinds, or for lazy days. Note that as I approach Social Security Benefits age, I may gear down a tooth or so.
I was younger -- ~ 48-50 -- but I found that a 67" gear was just right for pulling my then 2-4 year old daughter in a child trailer against headwinds -- given that headwinds inevitably turned into tailwinds.
For off road, shorter (sub 20 mile) rides on rolling terrain with some very steep but short hills, and sandy soil, I tried a 60" fixed drivetrain, which was alright for flats, nice for hills (I still had to walk the steeper or more sandy ones), but I hated, just hated the low gear for flats and tailwinds, esp since this bike had 175s instead of 170s. There are few experiences more discouraging than flailing despairingly on the flat with a tailwind in a 60" gear with 175 mm cranks. I found that 170s with a 63" or 65" gear was much better; you walk a wee bit more but the rest is far more comfortable. If I were to ride SS or fixed again in such conditions, I'd have a 65" gear with perhaps a 55" low for long climbs in sandy conditions.
A real off road bike is the one instance where I'd add a second chainring, and pair it with a large cog in back, to get a bigger gap between flatland cruising and technical stuff. Otherwise, I'd make do with a Dingle cog (IIRC, they come in 17/19 and 17/20) or a flipside cog. Again, it makes no sense to have 2 chainrings but only 1 cog.
Note that the S3X hub is a possibility -- direct high with 75% 2nd and 62.5% 1st; though it has its own liabilities, notably the annoying lash.
4. A few mm either way won't mar the chainline enough to cause problems, especially if you are using a modern bushingless chain. Cogs and rings are easily available in 3/32 width.
5. The right QRs are fine for fixed/ss wheels; just choose an old fashioned, internal cam, all steel one. External cam QRs won't hold and can be used only with vertical dropouts. If a QR can be used successfully with a derailleur drivetrain in a horizontal dropout, it will work with a fixed gear or ss drivetrain.
6. Relates to #3 (b): your gearing strategy. Me, I think it's foolish to ride a ss or fixie and then try to switch gears for every rise in the road. You have to decide for yourself where the breaking point is, but my own approach is to select a gear that is best for an entire ride, or a section of a ride, and just leave it there until I'm done. For example, I've got a couple of routes there the outbound involves climbing, the return downhills. I put the bike in the bigger cog outbound, and when I turn around, I switch.
Overall, and in all seriousness, fixed riding is really, really fun and, over the last 21 years, I've come to prefer it to riding multispeed; my only multispeed bike out of 4 is my dirt road bike, and even with that I often think of ss-ifying it. But if you're going to ride fixed, do it and get used to it; it involves a change not only of pedaling habits but of mindset -- and it's this last, really, that I find so attractive: you acquire the mental habit of doing more with less, which is pretty much the general definition of elegance. In particular, you learn to pace yourself for hills and winds; you learn to anticipate; you develop new techniques (the traditional idea of habitus, a more or less permanently acquired change in your soul and body or, if you don't understand those terms, your psychology and your physiology); and you find for example that you are quite sanguine about standing most of the way up a 5 mile climb. People on this list far more talented than I have done P-B-P on fixies and climbed the Rockies in amazingly huge fixed gears. It's a different style of riding, and you have to accept it for what it is and adapt to it -- and that gives the pleasure that derives from it.