Hi Joe.
I think you're right that if you have a good-fitting, comfortable 700C
bike and you can tweak off that in custom ways then you're bound to
get an excellent result. Changing to a smaller wheel size should, in
theory, feel odd initially but better because of the lowered center of
gravity. Though it's really not that much and the biggest thing that
will do that is a lower bottom bracket for a rando bike but I'm sure
your friend is keyed into that aspect, regardless of wheel size.
I'll give you my data point anyways. A year ago I decided I *needed*
a purpose built rando bike. Looked at 700C and 650B. Then a great
new frame, in the right size, at a good price presented itself to me.
Decision made. The frame was 650B but I shod it with 650A and haven't
looked back. Excellent quality (and nice looking) rims available in
that size. Not as many tire options as 650B, but there are a handful
of quality ones and once you find the one or two you need, the rest is
folly. I've put approximately 4,000 km on the bike so far, so that's
not a lot by your standards. But it has been an eye-opening year for
me and I'm leaning toward my next bike, a city bike re-build, being
650A also. The Panaracer Col de la Vie Randonee is a 38 mm tire,
nominally. I'm 5'11" and maybe 180 lbs. I run those tires at 55 PSI
and I can't say enough good things about the quality of the ride.
Haven't flatted yet. That surprised me. Rolling on smooth pavement
is amazing. And of course I don't sweat the cobblestones, gravel,
glass, or frost heaves when they appear. There are kevlar-lined
bulletproof tires available in this size also, by Schwalbe, and I have
a set. Slightly narrower but heavier and they have stiffer sidewalls
so they don't feel nearly as nice rolling.
Anyways, blah blah blah, you can tell I like this unusual size. I'm
sure I'd be equally happy with the slightly smaller 650B also
though... Just throwing a weird idea at you. Good luck!
The best edge you have is the frame builder friend. Wheel size is
just religion. Or is it physics? Who can tell, these days...
-Darren.