It may depend on how finicky you are about tire pressure, and how willing you are to top-off pressure mid-ride. Latex tubes reportedly lose around 0.5 to 1 percent per hour
. That seems about right in my experience. I used tubular tires with thin latex tubes for decades, and they needed pumping up every day. Wider tires and/or thicker latex tubes may extend that interval.
I've used latex tubes on 200k brevets without issue, but for anything longer I generally switch to butyl tubes or tubeless. Perhaps if I was aiming to "do a time", I might try them on a longer brevet since they do roll marginally faster. For me, it's not so much the hassle of reinflation that keeps me from using them on longer brevets, it's more about worry management. Who among us hasn't experienced soft-tire paranoia? You probably know what I mean: that dread feeling when you *imagine* your tire is starting to deflate, but you don't know for sure, and you really don't want to stop right now because (a) you're sitting on a friendly wheel, or (b) it's raining or (c) it's dark or (d) all of the above.
Eric in NH