I'd like to revisit Qubes OS and see if it's feasible to use as my primary OS again, but this time I'd like to know if DaVinci Resolve 14 (there are Windows, Mac, and Linux versions) can be installed either to run under Linux or under a Windows VM. People have gotten Resolve 14 to install and run under CentOS, Debian, Ubuntu, and other distributions.
I'd need audio to work.
If I could get youtube working with no performance or audio issues and DaVinci Resolve working on Qubes, I would gladly move to it full time.
Do you have to use this professionally or as a hobbyist?
Your complain regarding YouTube videos. I do not have issues with video or audio in YouTube videos.
Can you check if your audio settings where correct. I sometimes have issues, after I plugin other devices (e. g. microphone), afterwards my audio mixer is messed up. Which is easy to fix by adjusting the audio settings.
There's no hardware acceleration in any Qubes VM, so I doubt Photoshop and DaVinci Resolve will work. Additionally, I have no idea how this unholy mash of Xen/Fedora/Windows would manage color, if it would be end to end, or if you can even calibrate your display to get an accurate reproduction. No matter what, each virtual machine is essentially using the software renderer to talk to a fake output device, so performance is going to be very very limited and likely very poor.
There's currently no way to do PCI passthrough of graphics card to fix this, either, but that is an architectural and security decision and less of a software quality issue.
Short answer: I doubt that it works now, and I also doubt that it will work any time soon.