I'm asking because I want to know if there is a way or not.
To get some software to work properly it needs to be able to read certain parts of the system to get the identity and generate the keys to identify the pc as the pc to activate. I.E. it can't be run on multiple PCs, only the one that I registered it on.
what? lol
It depends on what exactly is used as input to creating this device identifier but it's extremely unlikely that you will be able to pass through all the necessary devices. You might be able to fake some of it, though. There is no support from qubes except for PCI passthrough.
Not really pertinent to this discussion but PUFs: https://en.wikipedia.org/wiki/Physical_unclonable_function
I don't want to pass through the device from dom0 to the guest, I jsut want everything that the guest sees to be the physical device that is faked to be as it really is. Not remove it from dom0 and everything else, because that would mean that qubes would stop working because the device isn't shared.