The downside to the XBox 360 for PC profile is you don't have simultaneous access to the mouse/keyboard functions, because it's like unplugging the quadstick and plugging in an XBox 360 controller when you activate the game profile.
X360CE allows game controller, mouse+keyboard, flash drive, even voice commands over USB, at the same time. It's just a more complicated setup.
Using a game controller vs keyboard/mouse with a PC game can give you easier to remember screen-hints (like A for jump), smoother character movement, and sometimes, easier play.
In your spreadsheet, repeat 27 is probably too fast (27 times per second). The default is 10 time per second, but you might experiment with lower numbers, like 3 or 4