No Qlab does the blending. The Datapath appears to your mac like a single hi resolution monitor
This shot shows the setup for 4 1280x720 projectors fed from a data path set up as a 2560x1440 screen (I don't have a Datapath in the studio so where it would say datapath it displays the device I am using which is a PA271W)

So you set up your projectors so they overlap by 20 percent which means the frame size of your video is actually 2304 x 1296
Your data path is set up as 2x2 your projector resolution of 1280x720 (2560x1440) and you use the partial screens to feed each quarter of the 2x2 Datapath with the correct image. Each of the blended edges will appear on 2 projectors. Here is the Bottom left partial screen feed

Mic