Hey Charles,
This is very possible in REAPER!
Here's how I do it. This way is easy when you get into the habit of it! There's another way to do it that eliminates the multichannel bus and makes each of your individual track an n-channel track, and you can route audio to the various channels through the FX rack, but I think this way below is the most intuitive.
1) Import your audio files into REAPER on separate tracks
2) Create a new track that will be your multichannel bus
3) Route each track to your multichannel bus, and remove the individual tracks from the master send. The only track that should be going to the master send is your multichannel bus. (Using the Routing Matrix makes this even quicker).
4) Open the multichannel bus routing and for each receive, choose a different set of channels to receive audio onto from your individual tracks, as in the attached screenshot.
5) Open routing for your master track and change the number of track channels to suit your application
6) Render the audio, using the WAV format, and type your desired channel count in the "channels" field.
In short, audio tracks -> multichannel bus -> main output. The multichannel bus, master track, and the render window all must reflect the channel count you are trying to achieve.
Let me know if you have questions!
Dan