Yes you can
In this example I am assuming you have a microphone connected to Claret input 1 and speakers (or a mixer) connected to Line outputs 1+2
I don't have a Clarett to hand, and am using an Octa-capture.. Where you see an Octa-capture in the screen shots, select your clarett instead
1. Select Interface in settings/audio/mic cues
2. Make a Mic cue. Patch it to your clarett.
Select the number of inputs and the starting ch e.g 1 input starting at input 1
Matrix that input to Line outputs 1+2 to route to your output connections on Line output 1+2
START THE CUE
Adjust Gain Knobs on clarett (and switch on phantom power if required) to get the meters peaking about 2 / 3 up the scale on the meters
That's it
Mic