If Mix control isn't loading it means that either the machine is not 'connecting' to the soundcard, or for some reason the driver/software is not starting correctly.
Make sure you are using the correct version of the software for both the OS and the Firmware on the Focusrite.
Try different usb ports on the Macs,
Try swapping the USB leads.
I must say that I have problems With our Saffire Pro 40 and our Mac Mini, almost every time it starts up the sound card is not recognised. Just because the Firewire light on the front of the unit is on, does not mean the card is up and running.
We always boot up the machine, and then turn on the soundcard afterwards, then open QLAB, this is the only way we have found it to work reliably.
However, that is Firewire not USB, but tbh It's probably a software bug / An OSX/core sound/something bug.
Hope this is helpful.
Dan