Hi Sandy,
Hm, it sounds like you'll need to trace the routing at each step to make sure it's going where you think it's going.
Specifically, check:
1) The cue's level matrix, where you route the channels of the file to the channels of the cue, and
2) The device's level matrix, where you route the channels of the cue to the channels of the device.
Beyond that, some devices also have their own routing options in the driver. If yours does, you'll need to check that too.
Best,
Chris