I don't understand. Do you mean launch Maya from the command line, with a lot of data as arguments to the call?
Command line calls are limited to 32k characters, I think, but you're still writing and reading all your matrix data as text, so I wouldn't expect it to be any faster.
Reading the data from a file using Python would be the best way to do it, I expect. If you're using the same data a lot of times you could read it once from a text file, then Pickle it into a binary file (or save it into a Maya binary), which would be a lot faster to read.