I don't think it can right out of the box. If the event queue turned into something more like asyncio then maybe. Pyinotify looks like it's blocking, so you probably need to use threading.
That notifier thread would need to publish data to a queue (perhaps one of Python's thread-safe queues) that you could examine every time simpy moves to the next event in the queue. Besides being hard since you'd need to modify the guts of simpy, you'll have to deal with a threaded process publishing to a queue, filtering that queue for events you don't care about (too old? are you yielding on file creates that instant response or else they might change again and you miss something?), and other stuff.
You might be able to subclass Event and yield on an event type that does that threading for you.
It might also be that whatever you're trying to accomplish has a better solution than simpy. There are lots of python task pipeline and automation libraries that may do what you want more directly.