Hi PG, you should be able to do it using win32com.
From the Excel 2003 VBA help:
"""
This example deletes Sheet3 in the active workbook without displaying
the confirmation dialog box.
Application.DisplayAlerts = False
Worksheets("Sheet3").Delete
Application.DisplayAlerts = True
"""
The operative line will after translation from VB to Python look
something like:
your_handle.Worksheets("Sheet3").Delete()
HTH,
John