Hi Dragos.
PyQtGraph through 0.11.1 supports Qt 4.7+ and Python 2.7+, just like 0.10.0. The next version (0.12.0) will only support Qt 5.12+ (including Qt6!) and Python 3.7+ and numpy 1.17+.
Future releases of pyqtgraph will follow a combination of
NEP-29 and Qt's own support schedule; although with their move for LTS version support only being for commercial customers, we will likely reconsider more on a case by case basis; so I'm not sure when we'll drop Qt 5.12 support, but it won't be for a while. I hope that helps.
Regarding API differences, there may be some minor differences, we've merged _hundreds_ of PRs between 0.10.0 and 0.11.1, but I don't think the API particularly changed.
Hope this helps.
Ogi