It's hard to help with this with so little information to go on. Are any error messages generated? PsychoPy generates log files, have you looked at them? After running an experiment in builder, it displays a console window that should include any system error messages. Does anything appear there?
If you're worried about memory, you could tell us how much RAM your computers have and give more specifics about your system. 64-bit computers generally offer more possibilities for handling large amounts of memory, so I wouldn't think the fact that it's 64 bit would cause problems, though I'm not an expert in the area (by the way, the processor (64 vs 32 bit) and the memory (RAM) are two separate things, in case you weren't sure).
Hopefully you'll get a better response if you can include more information that will help people think of potential causes of the problem. Take care,