Cases Only Dataset

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VIJAI JAI

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Jan 25, 2024, 7:38:13 PM1/25/24
to PRSice

I have a plink file on 1000 cases.
I also have a list of rsIDs of 25 SNPs that are genome-wide significant and with OR and pvalues.
I wanted to know if I can run PRSice on this data to generate a PRS per individual to create the standard histogram plots.

PRS=β1x1+β2x2++βkxk+βnxn

I just wanted quantiles of PRS and deviations from mean PRS (of the cases).
At a later date, I plan to use controls too. but for now, just needed for cases-only.
Is this possible?
Thanks
Jai

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