Gavin,
There are 2 variables that cannot be changed at runtime:
mysql-intefaces
mysql-threads
Changing those require a restart.
The right way of changing is:
UPDATE global_variables SET variable_value='0.0.0.0:6033;0.0.0.0:3308;0.0.0.0:3310;0.0.0.0:3311;0.0.0.0:3312;/tmp/proxysql.sock' WHERE variable_name='mysql-interfaces';
SAVE MYSQL VARIABLES TO DISK;
PROXYSQL RESTART;
Note that LOAD MYSQL VARIABLES TO RUNTIME should not be executed.
Thanks
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