Thank you for you quick response. Here's the result you asked:
MySQL [(none)]> SELECT * FROM stats_mysql_query_digest WHERE digest_text LIKE '%time%zone%'\G
*************************** 1. row ***************************
hostgroup: 0
schemaname: schema
username: dbuser
digest: 0xC7CC2EA40E54B940
digest_text: SELECT @@global.time_zone, @@session.time_zone, @@system_time_zone
count_star: 333
first_seen: 1510232854
last_seen: 1510232992
sum_time: 141765
min_time: 243
max_time: 2878
*************************** 2. row ***************************
hostgroup: 0
schemaname: schema
username: dbuser
digest: 0xC32A4EA4BA8FC9D1
digest_text: SET time_zone = ?
count_star: 595
first_seen: 1510232843
last_seen: 1510232952
sum_time: 0
min_time: 0
max_time: 0
2 rows in set (0.01 sec)
MySQL [(none)]> SHOW MYSQL STATUS;
+------------------------------+------------+
| Variable_name | Value |
+------------------------------+------------+
| Active_Transactions | 0 |
| Client_Connections_aborted | 0 |
| Client_Connections_connected | 0 |
| Client_Connections_created | 5017 |
| Client_Connections_non_idle | 0 |
| Com_autocommit | 0 |
| Com_autocommit_filtered | 0 |
| Com_backend_change_user | 326 |
| Com_backend_init_db | 0 |
| Com_backend_set_names | 0 |
| Com_backend_stmt_close | 0 |
| Com_backend_stmt_execute | 0 |
| Com_backend_stmt_prepare | 0 |
| Com_commit | 0 |
| Com_commit_filtered | 0 |
| Com_frontend_init_db | 0 |
| Com_frontend_set_names | 0 |
| Com_frontend_stmt_close | 0 |
| Com_frontend_stmt_execute | 0 |
| Com_frontend_stmt_prepare | 0 |
| Com_frontend_use_db | 4684 |
| Com_rollback | 0 |
| Com_rollback_filtered | 0 |
| ConnPool_get_conn_failure | 0 |
| ConnPool_get_conn_immediate | 389 |
| ConnPool_get_conn_success | 124150 |
| ConnPool_memory_bytes | 617584 |
| Mirror_concurrency | 0 |
| Mirror_queue_length | 0 |
| MySQL_Monitor_Workers | 16 |
| MySQL_Thread_Workers | 8 |
| ProxySQL_Uptime | 522 |
| Queries_backends_bytes_recv | 974640610 |
| Queries_backends_bytes_sent | 11938310 |
| Query_Cache_Entries | 0 |
| Query_Cache_Memory_bytes | 0 |
| Query_Cache_Purged | 0 |
| Query_Cache_bytes_IN | 0 |
| Query_Cache_bytes_OUT | 0 |
| Query_Cache_count_GET | 0 |
| Query_Cache_count_GET_OK | 0 |
| Query_Cache_count_SET | 0 |
| Query_Processor_time_nsec | 154559318 |
| Questions | 129853 |
| SQLite3_memory_bytes | 1882840 |
| Server_Connections_aborted | 0 |
| Server_Connections_connected | 7 |
| Server_Connections_created | 7 |
| Servers_table_version | 1 |
| Slow_queries | 0 |
| Stmt_Cached | 0 |
| Stmt_Client_Active_Total | 0 |
| Stmt_Client_Active_Unique | 0 |
| Stmt_Max_Stmt_id | 0 |
| Stmt_Server_Active_Total | 0 |
| Stmt_Server_Active_Unique | 0 |
| mysql_backend_buffers_bytes | 0 |
| mysql_frontend_buffers_bytes | 0 |
| mysql_session_internal_bytes | 21376 |
+------------------------------+------------+
60 rows in set (0.00 sec)