Antidote York

[Shawana Messerli]

MISSIONSTORY: Once upon a time there lived a wise woman whose mission was to make the world healthier. She had concocted an antidote chocolate using unique ingredients and rare spices that had never been combined before. Casting a powerful spell, she bestowed her creation with miraculous healing properties that could cure any ailment.

With word of the magical remedy quickly spreading throughout the world, people from all corners eagerly sought out the woman in hope of experiencing its power firsthand. It did not take long for merchants to start selling this coveted Antidote Chocolate in stores, available to those in need of healing.

A serendipitous text message calling for an Antidote prompted me to create a true mood boosting super chocolate that is loaded with exquisite and antioxidant filled cacao and real flavor toppings. Friends and family waited in anticipation to taste my latest batch as I experimented in my kitchen: conching and tempering, and coming up with the perfect combinations of chocolate, herbs, and spices.

Soon my quaint apartment permeated with aromatic delight as boxes of the finest ingredients from around the world piled up. Nine month into my journey, I settled on the world-renowned Arriba Nacional beans for their wonderful floral and fruity aroma. Not long after, I packed my bags and left for Ecuador with a recipe and original flavors in hand.

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A structure of the Escherichia coli chromosomal MazE/MazF addiction module has been determined at 1.7 A resolution. Addiction modules consist of stable toxin and unstable antidote proteins that govern bacterial cell death. MazE (antidote) and MazF (toxin) form a linear heterohexamer composed of alternating toxin and antidote homodimers (MazF(2)-MazE(2)-MazF(2)). The MazE homodimer contains a beta barrel from which two extended C termini project, making interactions with flanking MazF homodimers that resemble the plasmid-encoded toxins CcdB and Kid. The MazE/MazF heterohexamer structure documents that the mechanism of antidote-toxin recognition is common to both chromosomal and plasmid-borne addiction modules, and provides general molecular insights into toxin function, antidote degradation in the absence of toxin, and promoter DNA binding by antidote/toxin complexes.

I teach philosophy at the City College of New York, an institution which, since its founding in 1847, has attracted a student body as diverse as the city it serves. Many of my students come from minority, low-income, or immigrant communities; some all three. They are strivers - seeking an education in order to become health professionals, teachers, engineers, or lawyers while holding onto jobs and taking care of families. Most of them are more fortunate than our imagined protagonist, but for many of them going to university involves great personal and financial sacrifices. Given that few of my students will ultimately find their way into the academy and that, within that already small cohort, only a fraction will choose to do so in the field of philosophy, the question of why study philosophy has a particular resonance for them, and for me as their teacher.

One answer to this question is pragmatic - philosophy teaches you to think and write logically and clearly. This, we tell our students, will be of use to them no matter what path they pursue. We advertise philosophy, then, as a broadly useful means to a variety of ends. There is a lot of truth to this dispassionate answer, but it is also rather disappointing. It sells philosophy short. A different sort of answer dives into profundity - philosophy aims to discover fundamental truths. Many disciplines aim at knowledge but philosophers, we solemnly tell our students, go deeper - we seek Knowledge with a capital K. This is undeniably the goal of many philosophers, but it can alienate some students (in particular, those who are not interested in pursuing an academic career). Why, these students might ask, is the knowledge that philosophy aims at any deeper than that of more practical fields such as medicine, science, or the law? And why should they care about this kind of knowledge? Even if most professional philosophers aim at the deepest kind of knowledge, this does not show that it is a valuable enterprise for all students, especially for those who are already overcoming significant hurdles to attend university.

There is a third kind of answer that, without competing with the previous two, demonstrates the value of philosophy, even (perhaps, especially) for students like our imagined protagonist: philosophy is the antidote to the uncritical acceptance of the world and ourselves as we are. This answer falls squarely within the classical tradition of philosophy as an ethical and political enterprise. And if it is right, it is students like the one imagined above, with little time and few resources, who have the most to gain from philosophy, because it is they who stand to lose the most if the world stays as it is.

However, if philosophy is to serve as an antidote to the resigned acceptance of injustice, a philosophical education must embrace the constructive imagination. We fail if all we teach students is to be critical. We need to enable our students to conceive of a different and better way for things to be. One of the most powerful defenders of social justice in the twentieth century, Martin Luther King Jr, held up hope in the form of a dream. He imagined a possibility that was different than the reality he experienced and held it up as a beacon. Philosophy at its best enables students to find their beacon.

Praised by leading outlets like Rolling Stone, TIME, Interview Magazine, and more, acclaimed singer-songwriter FLETCHER hails from Asbury Park, New Jersey, where she cultivated her passion for music and her unforgettably candid storytelling. In 2019 she released her widely lauded debut EP you ruined new york city for me, featuring her breakthrough hit "Undrunk" -- a track that spent several weeks on the Billboard Hot 100, scored the No.1 spot on Spotify's Viral Chart, and emerged as the fastest-rising song at pop radio from a new artist in the past five years. Released in September 2020, FLETCHER's EP THE S(EX) TAPES hit No. 1 on iTunes across all genres and included the hit single "Bitter," which has amassed over 200 million global streams. FLETCHER's debut album Girl Of My Dreams arrived in September 2022 and delivered the smash single "Becky's So Hot," which hit No. 3 on the iTunes chart across all genres and landed on Billboard's Hot Rock and Alternative Songs chart. The album earned raves from the likes of Rolling Stone, Billboard, Alternative Press, Vulture, and many others while her music has surpassed two billion combined streams worldwide. In support of the LP, FLETCHER performed on "The Tonight Show Starring Jimmy Fallon" and set out on sold-out headline tours across North America, Australia, and Europe with nearly 200K tickets sold to date. FLETCHER kicked off 2023 with an internet-breaking performance alongside Miley Cyrus on NBC's "New Year's Eve Party," won the 2023 GLAAD Media Award for Outstanding Music Artist and garnered nominations from the MTV Video Music Awards and MTV Europe Music Awards. A fast-rising cultural force, she also appeared as herself in the third season of The L Word: Generation Q on Showtime, launched her own "FLETCHER & Friends" festival in her hometown of Asbury Park, and raised over $200K for GLAAD as part of her hugely popular Meet Her At The Bar: Pride Month Experience-- a series of pop-ups in support of women-owned queer bars across America. FLETCHER will begin her global headline tour of the UK, Europe and Australia tour this spring with performances at Lollapalooza South America in Brazil, Chile and Argentina in March. FLETCHER's sophomore album In Search Of The Antidote will be released March 22 on Capitol Records.

During the first months of the Covid outbreak in early 2020, and then as a bitterly contested presidential election tested the very soul of American democracy, I rediscovered the balm of reading fiction. Not as an escape from the constant press of dreadful news, but as an antidote. Fiction can provide insight, instruction, and inspiration, even as it takes our minds from the anxiety of the moment.

Of course, some of those literary sacred cows have been supplanted by a new generation of modern classics, an alternative canon that is more inclusive of overlooked women writers as well as people of color and gay writers.

Early in the pandemic, I began reading one tale a day from the Decameron. And I realized that Boccaccio was on to something. There is a liberating quality about brief tales told in the midst of a pandemic. From Boccaccio, I moved on to short novels.

Based on my reading experience over a year in lockdown, and considerable research, I curated a guide to some of the greatest short fiction from around the world and published in English, including a broad diversity of writers and voices. As I define them, short novels encompass fiction of one hundred to two hundred pages.

A short novel is like a great first date. It can be extremely pleasant, even exciting, and memorable. Ideally, you leave wanting more. It can lead to greater possibilities. But there is no long-term commitment.

Short can be masterful. Short can be rewarding. Evidence of that fact is the inclusion of several Pulitzer-winning books and eleven Nobel Prize winners in my collection Great Short Books. The short work of such Nobel laureates as Thomas Mann, Ernest Hemingway, Nadine Gordimer, Doris Lessing, Toni Morrison, and Kazuo Ishiguro offers ample evidence of why these literary virtuosos won their accolades.

Join the American Academy of Clinical Toxicology (AACT) and ACMT on Wednesday, April 10, 2024 for a Symposium on "Antidote Shortages: Impact & Response." This half-day symposium gathers experts, researchers, healthcare professionals, and policymakers committed to addressing the critical issue of antidote shortages in our healthcare system. Attendees will engage in insightful discussions on the root causes and far-reaching consequences of these shortages, examining their effects on patient care, healthcare economics, and public health. Furthermore, the symposium will spotlight cutting-edge solutions and collaborative approaches aimed at mitigating these shortages, fostering resilience in healthcare systems, and ensuring timely access to life-saving antidotes. Together, participants will work towards building a more robust and responsive healthcare infrastructure that can effectively combat antidote shortages and safeguard patient well-being.

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