In Orbitrap instruments, my understanding is that the ~3.5 orders of magnitude instrascan dynamic range can be intuitively explained by the fact that physical trap can hold only so many ions, and therefore once the very high-abundant ions fill up a trap, there's simply no more space left for the very low abundant ions; hence, the dynamic range is limited accordingly (at least for instrascan perspective).
For QTOFs (especially the Sciex 5600 and 6600), though, what's limiting the dynamic range (I believe is has something to do with "detector saturation" but I don't really know what that means)? Also, unlike Orbitraps, does the dynamic range impact the *high abundant* ions by "saturating their signal" but does *not* impact the low-abundant ions? (If so, does that imply that if one is interested primarily in low-abundant signals, the QTOFs have an inherent advantage? Or, is that advantage limited by the fact that, due to ion statistics, the QTOFs require a MINIMUM number of ions before it will produce a usable signal, and that "minimum number of ions" would therefore require a sizable dwell time for very low-abundant ions?) Also, for QTOFs, if the dynamic range is limited due to "detector saturation", how quickly does that "saturation effect" get reset? That is, is that "detector saturation" reset on every QTOF push? Or does it take a few miliseconds to reset itself? (I am almost certainly not using the "correct" terminology here, but hopefully my questions are sufficiently clear to trigger an informative discussion/answer etc.)