New ProteomeXchange dataset PXD070547

[ProteomeCentral Agent]

Dear ProteomeXchange subscriber, a new ProteomeXchange dataset is being announced. To see more information, click here:

https://proteomecentral.proteomexchange.org/dataset/PXD070547

Summary of dataset

Status: new
Identifier: PXD070547
HostingRepository: PRIDE
Species: Homo sapiens
Title: A comprehensive landscape of human organ N-glycoproteome
Submitter: hu xiaoyu
LabHead: Zhixin Tian
Description: N-glycosylation, as a common post-translational modification with enormous structures, plays key roles in protein folding, cellular recognition and signaling pathways. State-of-the-art mass spectrometry-based N-glycoproteomics has enabled deep N-glycoproteome characterization of various human organs. However, a comprehensive N-glycoproteome landscape of human organs remains lacking. Here we present a systematic human N-glycoproteome atlas spanning 18 organs/tissues with identification of 31,003 intact N-glycopeptides, corresponding to 14,043 N-glycan monosaccharide compositions on 5,539 N-glycosites of 3,681 N-glycoproteins. Tissue-specific glycosylation patterns, novel glycoforms and crosstalk between sialylation and fucosylation are observed. This atlas, complemented by a unified multi-software analysis framework, provides insights into organ-specific glycobiology and establishes a fundamental reference for understanding physiological glycosylation characteristics of h
uman tissues.

HTML_URL: https://proteomecentral.proteomexchange.org/dataset/PXD070547
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