New ProteomeXchange dataset PXD071578

[ProteomeCentral Agent]

Dear ProteomeXchange subscriber, a new ProteomeXchange dataset is being announced. To see more information, click here:

https://proteomecentral.proteomexchange.org/dataset/PXD071578

Summary of dataset

Status: new
Identifier: PXD071578
HostingRepository: MassIVE
Species: Homo sapiens
Title: Age-Dependent Effects of Fibroblast-Derived Exosomes on Keratinocyte Differentiation
Submitter: Page
LabHead: Jerome LAMARTINE
Description: Skin aging is driven by both extrinsic factors, such as ultraviolet exposure, and intrinsic, chronological processes that lead to progressive deterioration in skin homeostasis and structure. Chronological aging is associated with replicative senescence and a range of molecular and cellular alterations, including genomic instability, mitochondrial dysfunction, and impaired intercellular communication. The dynamic cross-talk between dermal fibroblasts and epidermal keratinocytes is crucial for maintaining skin integrity throughout aging, with extracellular vesicles (EVs) emerging as key mediators of this intercellular communication. While the impact of keratinocyte-derived EVs in modulating dermal fibroblast function is increasingly recognized, the reciprocal influence of fibroblast-derived EVs on keratinocytes remains largely unexplored, particularly in the context of aging. In this study, we isolated and characterized small EVs, mainly exosomes, from primary human dermal
fibroblasts derived from young and aged donors. We analyzed their size, molecular composition, and age-related differences, and assessed their effects on keratinocyte function.

HTML_URL: https://proteomecentral.proteomexchange.org/dataset/PXD071578
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