New ProteomeXchange dataset PXD072389

[ProteomeCentral Agent]

Dear ProteomeXchange subscriber, a new ProteomeXchange dataset is being announced. To see more information, click here:

https://proteomecentral.proteomexchange.org/dataset/PXD072389

Summary of dataset

Status: new
Identifier: PXD072389
HostingRepository: iProX
Species: Mus musculus
Title: Proteomic profiling of extracellular vesicles derived from TGF-β-treated mouse aortic endothelial cells
Submitter: Ruoyun Tan
LabHead: Ruoyun Tan
Description: Endothelial cell dysfunction plays a critical role in the pathogenesis of chronic allograft dysfunction and tissue fibrosis. Autophagy deficiency in endothelial cells has been implicated in altered extracellular vesicle (EV) cargo composition, which may contribute to pericyte-to-myofibroblast transition. In this study, we performed quantitative proteomic analysis of EVs isolated from the culture supernatant of mouse aortic endothelial cells (MAECs) treated with or without TGF-β to identify differentially expressed proteins. EVs were isolated by ultracentrifugation and characterized according to MISEV2023 guidelines. LC-MS/MS-based proteomics was performed to compare the protein profiles between control (NC) and TGF-β-treated groups. This dataset provides insights into the molecular cargo alterations in endothelial cell-derived EVs under pro-fibrotic conditions.

HTML_URL: https://proteomecentral.proteomexchange.org/dataset/PXD072389
XML_URL: https://proteomecentral.proteomexchange.org/dataset/PXD072389&outputMode=XML