New ProteomeXchange dataset PXD062291

[ProteomeCentral Agent]

Dear ProteomeXchange subscriber, a new ProteomeXchange dataset is being announced. To see more information, click here:

https://proteomecentral.proteomexchange.org/dataset/PXD062291

Summary of dataset

Status: new
Identifier: PXD062291
HostingRepository: iProX
Species: Homo sapiens
Title: Catalytic mechanism of an Actin-dependent adenylyltransferase involved in ubiquitin signaling
Submitter: Jiaqi Fu
LabHead: Jiaqi Fu
Description: The two effectors LnaB and MavL of Legionella pneumophila coordinate the conversion of phosphoribosyl ubiquitin (PR-Ub) released by reversal of ubiquitination induced by members of the SidE effector family into functional Ub. LnaB acts as an actin-dependent phosphoryl AMPylase that converts PR-Ub into ADP-ribosylated (ADPR)-Ub. Catalysis by LnaB requires the novel conserved S-HxxxE motif present in a large family of bacterial toxins. Here we uncovered a novel adenylylation mechanism involved in two-step ATP hydrolysis.

HTML_URL: https://proteomecentral.proteomexchange.org/dataset/PXD062291
XML_URL: https://proteomecentral.proteomexchange.org/dataset/PXD062291&outputMode=XML