Status: new
Identifier: PXD035691
HostingRepository: PRIDE
Species: Homo sapiens
Title: Phosphoproteomics Reveals the Wolframin-Calcium Axis as a Key Pathogenic Signaling Node in Primary Aldosteronism
Submitter: 溢 杨
LabHead: Yang Yi
Description: Using 4D label-free quantitative proteomics technique, combined with bioinformatics, we generated in-depth proteome and phosphoproteome signaling network maps of aldosterone-producing adenoma and nonfunctioning adrenocortical tumor. We identified wolframin-calcium axis as a key regulatory node in aldosterone synthase activation and aldosterone hypersecretion.