New ProteomeXchange dataset PXD072374

[ProteomeCentral Agent]

Dear ProteomeXchange subscriber, a new ProteomeXchange dataset is being announced. To see more information, click here:

https://proteomecentral.proteomexchange.org/dataset/PXD072374

Summary of dataset

Status: new
Identifier: PXD072374
HostingRepository: iProX
Species: Rattus rattus
Title: Multi-omics data of BPD-PH mouse model
Submitter: Siqi Hu
LabHead: Qiuping Li
Description: Integrated multi-omics analysis identified 820 differentially expressed genes, 558 differentially expressed proteins, and 1,377 differential metabolites/lipids, which were mainly enriched in pathways related to inflammation and immunity, cellular signal transduction, ferroptosis, and HIF-1 signaling. TRIM21 emerged as a central molecule exhibiting significant dynamic upregulation in the early (hyperoxic) stage and downregulation in the late (hypoxic) stage of BPD-PH. Further validation in animal models, cellular experiments and clinical samples confirmed a marked elevation of TRIM21, IL-6 and IL-8 expressions in early-stage BPD-PH infants. Mechanistic study revealed that hyperoxia induced TRIM21 upregulation, enhanced NF-κB signaling activation, and promoted PASMC proliferation and migration, while TRIM21 and NF-κB activity was decreased during later disease stages. All these data demonstrate that TRIM21 orchestrated BPD-PH inflammation and vascular remodeling in a dyn
amic manner of early activation and late inhibition, suggesting TRIM21 as a promising molecular target and providing mechanistic insights for the precise diagnosis and treatment of BPD-PH.

HTML_URL: https://proteomecentral.proteomexchange.org/dataset/PXD072374
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