New ProteomeXchange dataset PXD058734

[ProteomeCentral Agent]

Dear ProteomeXchange subscriber, a new ProteomeXchange dataset is being announced. To see more information, click here:

https://proteomecentral.proteomexchange.org/dataset/PXD058734

Summary of dataset

Status: new
Identifier: PXD058734
HostingRepository: PRIDE
Species: Mus musculus
Title: Targeted KRAS(G12V) degradation elicits efficient and durable lung adenocarcinoma regression in vivo
Submitter: Marta Vilaseca
LabHead: Marta Vilaseca
Description: Recent drug discovery breakthroughs led to the approval of KRASG12C inhibitors in lung adenocarcinoma (LUAD). Unfortunately, clinical responses remain limited due to rapid resistance onset. Proteolysis-targeting chimeras (PROTACs) have emerged as promising alternatives to traditional inhibition. However, there is limited mechanistic understanding of KRAS degradation in vivo. Here, we developed a preclinical LUAD mouse model and demonstrated that targeted KRAS degradation induces rapid tumor regression. Transcriptional and histological analyses revealed a substantial remodeling of the tumor microenvironment. Notably, the low resistance rate observed during long-term treatment stems from proteolysis machinery dysregulation rather than KRAS absence adaptation, indicating resistance mechanisms distinct from KRAS inhibition. Our findings highlight the therapeutic potential of KRAS degradation in LUAD, offering insights into cell-intrinsic and extrinsic mechanisms driving dura
ble antitumor responses and supporting further clinical exploration.

HTML_URL: https://proteomecentral.proteomexchange.org/dataset/PXD058734
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