New ProteomeXchange dataset PXD052932

[ProteomeCentral Agent]

Dear ProteomeXchange subscriber, a new ProteomeXchange dataset is being announced. To see more information, click here:

https://proteomecentral.proteomexchange.org/dataset/PXD052932

Summary of dataset

Status: new
Identifier: PXD052932
HostingRepository: PRIDE
Species: Canis familiaris (Canis lupus familiaris)
Title: A Labrador PeptideAtlas - resource for proteomics research in dogs
Submitter: Ulrike Kusebauch
LabHead: Robert L.
Description: The domestic dog, Canis lupus familiaris, plays a vital role as companion or service animal, and the well-being and healthy aging of dogs is gaining importance. Proteins are key actors in cells, tissues and body fluids, and the ability to measure their composition and abundance is crucial to understand biological processes. We report a mass spectrometry-based proteomics approach analyzing canine tissue, plasma and urine to develop two comprehensive resources to advance the study of the dog proteome. Firstly, we developed a canine PeptideAtlas covering 49% of the predicted UniProt KB proteome and secondly, a spectral assay library for targeted applications by data-independent acquisition (DIA) that enables the identification and quantification of 11,792 proteins (11,564 protein groups) of the dog proteome (56%). We demonstrate the performance of the library with gradients of different length and quantify 10,140 proteins in tissue and 385 proteins in plasma.

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