New ProteomeXchange dataset PXD036676

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Dear ProteomeXchange subscriber, a new ProteomeXchange dataset is being announced. To see more information, click here:

http://proteomecentral.proteomexchange.org/dataset/PXD036676

Summary of dataset

Status: new
Identifier: PXD036676
HostingRepository: PRIDE
Species: Staphylococcus aureus
Title: Staphylococcus aureus prophage-encoded protein causes abortive infection and provides population immunity against kayviruses
Submitter: PetrGintar
LabHead: ZbynekZdrahal
Description: The aim of the study was to investigate the resistance mechanism of Staphylococcus aureus towards lytic phages of the genus Kayvirus and the role of the membrane-anchored protein (primary accession Q2FYE0) designated PdpSau encoded by Staphylococcus aureus prophages. PdpSau does not prevent the infecting kayvirus from adsorbing onto the host cell and delivering its genome into the cell, but phage DNA replication is halted. Changes in the cell membrane polarity and permeability were observed 10 min after the infection leading to prophage-activated cell death. The LC-MS/MS analysis, as one of the methods, was used for protein detection and to find out whether this protein is predominantly presented in membranes. These findings are relevant for the advancement of phage therapy.

HTML_URL: http://proteomecentral.proteomexchange.org/dataset/PXD036676
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