New ProteomeXchange dataset PXD073843

[ProteomeCentral Agent]

Dear ProteomeXchange subscriber, a new ProteomeXchange dataset is being announced. To see more information, click here:

https://proteomecentral.proteomexchange.org/dataset/PXD073843

Summary of dataset

Status: new
Identifier: PXD073843
HostingRepository: PRIDE
Species: Homo sapiens , Plasmodium falciparum (isolate 3D7)
Title: Phosphoproteomics of Plasmodium falciparum infected red blood cells under Heat Stress
Submitter: David Jones
LabHead: Moritz Treeck
Description: This project investigates changes in protein phosphorylation in the malaria parasite Plasmodium falciparum in response to heat stress. During infection parasites are exposed to febrile temperatures in the human host. Heat stress is known to trigger adaptive responses but the role of protein phosphorylation in this process is not fully understood. The aim of this study is to identify phosphorylation events that change following exposure to elevated temperature. Synchronous asexual blood stage parasites were exposed to heat stress and compared with parasites maintained at normal culture temperature. Parasites were harvested after heat stress and proteins were extracted and digested into peptides. Phosphopeptides were enriched prior to analysis by liquid chromatography coupled to tandem mass spectrometry. The resulting data provide a global view of phosphorylation changes associated with heat stress in P. falciparum. This dataset enables the identification of heat responsiv
e phosphosites and supports analysis of signalling pathways and regulatory processes that may contribute to parasite adaptation to febrile conditions.

HTML_URL: https://proteomecentral.proteomexchange.org/dataset/PXD073843
XML_URL: https://proteomecentral.proteomexchange.org/dataset/PXD073843&outputMode=XML