New ProteomeXchange dataset PXD069579

[ProteomeCentral Agent]

Dear ProteomeXchange subscriber, a new ProteomeXchange dataset is being announced. To see more information, click here:

https://proteomecentral.proteomexchange.org/dataset/PXD069579

Summary of dataset

Status: new
Identifier: PXD069579
HostingRepository: iProX
Species: Drosophila melanogaster
Title: Proteomic Profiling of an ALS Drosophila Model Reveals the Impact of Scaffold Degrader P3 on Head Tissue
Submitter: YingChen Zhou
LabHead: JiaHeng Tan
Description: This project presents a quantitative proteomic analysis of Drosophila melanogaster head tissue expressing human FUS-P525L, using data-independent acquisition (DIA) mass spectrometry. To enable identification of the human transgene, mass spectrometry data were analyzed against a custom database containing the Drosophila melanogaster proteome (UniProt UP000000803) and the human FUS sequence. Head samples were processed through protein extraction, acetone precipitation, and in-solution tryptic digestion. LC-MS/MS data were acquired on a Thermo Scientific instrument and analyzed with the DIA-NN software (v1.8.1), with FDR controlled at 1%. The dataset enables the investigation of protein expression changes, including the transgenic human FUS, under P3 treatment.

HTML_URL: https://proteomecentral.proteomexchange.org/dataset/PXD069579
XML_URL: https://proteomecentral.proteomexchange.org/dataset/PXD069579&outputMode=XML