New ProteomeXchange dataset PXD067614

[ProteomeCentral Agent]

Dear ProteomeXchange subscriber, a new ProteomeXchange dataset is being announced. To see more information, click here:

https://proteomecentral.proteomexchange.org/dataset/PXD067614

Summary of dataset

Status: new
Identifier: PXD067614
HostingRepository: PRIDE
Species: Homo sapiens
Title: Cooperative Aldehyde Chemistry Maps an Orthogonal Lysine Reactivity Landscape
Submitter: Riley Hughes
LabHead: Monika Raj
Description: Reactive metabolites are often associated with nonspecific protein damage, if harnessed cooperatively they could be repurposed into precision tools for targeted labeling, redefining how we probe and manipulate protein function in complex biological systems. Here, we introduce a bioinspired cooperative metabolite strategy that harnesses the synergistic chemistry of malondialdehyde (MDA) and monoaldehydes to generate highly reactive intermediates that selectively modify lysine residues across proteins and proteomes. Dose-dependent chemoproteomic profiling of proteins modified by MDA-monoaldehyde complexes reveals 245 peptides and 167 unique proteins commonly modified in all doses. Among these, nearly 100 proteins feature a single modification at only hyperreactive lysine residue, indicating distinct microenvironmental features that enhance lysine reactivity and selectivity toward cooperative metabolite modification. Captured proteins were found to be linked to disease path
ways and environmental exposures, revealing previously unrecognized patterns of metabolic susceptibility. 

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