New ProteomeXchange dataset PXD070502

[ProteomeCentral Agent]

Dear ProteomeXchange subscriber, a new ProteomeXchange dataset is being announced. To see more information, click here:

https://proteomecentral.proteomexchange.org/dataset/PXD070502

Summary of dataset

Status: new
Identifier: PXD070502
HostingRepository: PRIDE
Species: Homo sapiens
Title: Multi-omics profiling of the host response to Leptospira infection in human PBMCs
Submitter: Faisal Syed M
LabHead: Syed M. Faisal
Description: This study provides a comprehensive multi-omics analysis of the human host response during acute leptospirosis. We performed integrated transcriptomic and proteomic profiling of peripheral blood mononuclear cells (PBMCs) from clinically confirmed leptospirosis patients and healthy controls. Our analysis reveals widespread dysregulation of host pathways, including potent activation of TNF-alpha/NF-kappaB signaling, interferon responses, and inflammatory and immunometabolic pathways. We identified a conserved core host response signature, validated key immune mediators in an ex vivo whole-blood infection model, and pinpointed a multi-protein signature associated with the disease. This dataset offers a valuable resource for understanding the molecular mechanisms of host-pathogen interactions in leptospirosis and identifies potential biomarkers and therapeutic targets.

HTML_URL: https://proteomecentral.proteomexchange.org/dataset/PXD070502
XML_URL: https://proteomecentral.proteomexchange.org/dataset/PXD070502&outputMode=XML