New ProteomeXchange dataset PXD079232

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Dear ProteomeXchange subscriber, a new ProteomeXchange dataset is being announced. To see more information, click here:

https://proteomecentral.proteomexchange.org/dataset/PXD079232

Summary of dataset

Status: new
Identifier: PXD079232
HostingRepository: PRIDE
Species: Homo sapiens
Title: Towards a proteomic plasma biomarker panel for diagnosing vasculitis remission
Submitter: Marieluise Kirchner
LabHead: Philipp Mertins
Description: Active anti-neutrophil cytoplasmic autoantibody (ANCA)-associated vasculitis (AAV) requires intensive immunosuppressive therapy, but continued treatment after remission is achieved can cause serious harm. Reliable biomarkers to confirm remission are lacking, forcing clinicians to prolong cost-intensive and toxic therapy unnecessarily. Routine markers, such as C-reactive protein and anti-neutrophil cytoplasmic antibodies, lack sensitivity and specificity for the remission status, failing to guide treatment de-escalation safely. After adjusting for patient characteristics and clinical variables, we explored the plasma proteome to identify reliable biomarkers of disease remission in patients with AAV. We applied a two-tiered proteomics strategy combining global discovery with targeted validation to identify a protein signature of remission. The resulting 7-protein panel was successfully implemented in a targeted mass spectrometry-based assay, with diagnostic performance con
firmed in an independent patient cohort. The panel consistently outperformed routine markers. Our findings suggest that this panel may serve as a starting point for developing a clinical tool to support decision-making, with the potential to reduce treatment-related burden, mitigate toxicity, and lower healthcare costs. Moreover, our confounder-controlled proteomics approach provides a scalable blueprint for biomarker discovery in complex inflammatory diseases.

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