New ProteomeXchange dataset PXD072412

[ProteomeCentral Agent]

Dear ProteomeXchange subscriber, a new ProteomeXchange dataset is being announced. To see more information, click here:

https://proteomecentral.proteomexchange.org/dataset/PXD072412

Summary of dataset

Status: new
Identifier: PXD072412
HostingRepository: iProX
Species: Mus <genus>
Title: GSNOR drives age-related obesity by promoting adipose tissue whitening through de-nitrosation of Beclin-1
Submitter: Shilong Li
LabHead: Chang Chen
Description: Age-related obesity is a growing public health concern since it contributes to a multitude of metabolic disorders, yet its mechanisms remain poorly defined. Herein, we report that S-nitrosoglutathione reductase (GSNOR), a pivotal enzyme for de-nitrosation, significantly increased in adipose tissues in both naturally middle-aged mice and human. Knocking out (KO) GSNOR in mice leads to weight reduction, diminished adipose mass and improved metabolism, while adipose tissue-specific overexpression of GSNOR (KI) results in obesity and metabolism decline. Further study showed that aged GSNOR KO mice had higher mitochondrial content and beige adipocytes, but adipose-specific GSNOR overexpression promoted adipose tissue whitening. Quantitative S-nitrosation proteomic analysis indicate S-nitrosation of Beclin-1 at cysteine 351 decreased significantly in aging mice and GSNOR KI mice. Beclin-1C351A mutation promoted autophagy by facilitating the interaction between Beclin-1 and AT
G14, thereby accelerating the conversion of beige to white adipocytes. Notably, age-related obesity is abrogated by specific knocking down GSNOR in adipose tissue. This study reveals a new mechanism and a novel therapeutic avenue for managing age-related obesity.

HTML_URL: https://proteomecentral.proteomexchange.org/dataset/PXD072412
XML_URL: https://proteomecentral.proteomexchange.org/dataset/PXD072412&outputMode=XML