New ProteomeXchange dataset PXD078319

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Dear ProteomeXchange subscriber, a new ProteomeXchange dataset is being announced. To see more information, click here:

https://proteomecentral.proteomexchange.org/dataset/PXD078319

Summary of dataset

Status: new
Identifier: PXD078319
HostingRepository: iProX
Species: Klebsiella sp.
Title: multi-omics analysis of zinc tolerance and the maintenance of high-efficiency denitrification in Klebsiella sp. WH-E under Zn²⁺ stress
Submitter: Lancheng Cao
LabHead: Likun Sun
Description: This study systematically evaluated the denitrification performance and tolerance mechanisms of the highly efficient heterotrophic nitrifying–aerobic denitrifying strain Klebsiella sp. WH-E under Zn²⁺ stress. Under 100 mg/L Zn²⁺ stress, the heterotrophic nitrification and aerobic denitrification capabilities of Klebsiella sp. WH-E resulted in an ammonia nitrogen removal rate of 95.53% and a nitrate nitrogen removal rate of 74.00%. and the nitrite nitrogen removal rate was 72.75%. The activities of the key denitrification enzymes NAR and NIR remained largely stable, and the accumulation of NO₃⁻-N and NO₂⁻-N during nitrogen transformation was limited. Multi-omics analysis revealed that Zn²⁺ stress significantly upregulated nitrogen metabolism-related genes (narG, nirB) and metal homeostasis regulatory genes (zntA, arsR, czcC), while simultaneously regulating ABC transporters and two-component systems to maintain intracellular Zn²⁺ homeostasis. The abu
ndance of sulfur metabolism and antioxidant-related metabolit

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