New ProteomeXchange dataset PXD061137

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Dear ProteomeXchange subscriber, a new ProteomeXchange dataset is being announced. To see more information, click here:

https://proteomecentral.proteomexchange.org/dataset/PXD061137

Summary of dataset

Status: new
Identifier: PXD061137
HostingRepository: PRIDE
Species: Homo sapiens
Title: Neo N-termiome of SPG7, AFG3L2, SPG7 AFG3L2 and WT HeLa cells
Submitter: Hendrik Nolte
LabHead: Thomas Langer
Description: To understand how OMA1 affects mitochondrial proteostasis and stress responses, we performed a proteomic survey of OMA1-deficient cells for proteolytic substrates. We demonstrate that OMA1 cleaves the mitochondrial chaperone DNAJC15 facilitating its degradation by the mitochondrial m-AAA protease. The loss of DNAJC15 alters protein import by TIM23 protein translocases in the IM and limits the accumulation of OXPHOS-related mitochondrial matrix and IM proteins. Non-imported mitochondrial preproteins accumulate at the endoplasmic reticulum (ER) and trigger an ATF6-related unfolded protein response. These results demonstrate that OMA1 allows to adapt mitochondrial protein biogenesis to stress and reveal an intricate network of cellular stress responses to proteostasis disturbances. In this dataset, we determined the Neo N termiome of SPG7, AFG3L2 and SPG7 AFG3L2 knock out HeLa cells. The project is related to other identfiers PXD061131, PXD061134.

HTML_URL: https://proteomecentral.proteomexchange.org/dataset/PXD061137
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