New ProteomeXchange dataset PXD065872

[ProteomeCentral Agent]

Dear ProteomeXchange subscriber, a new ProteomeXchange dataset is being announced. To see more information, click here:

https://proteomecentral.proteomexchange.org/dataset/PXD065872

Summary of dataset

Status: new
Identifier: PXD065872
HostingRepository: jPOST
Species: Mus musculus
Title: Intranasal administration of balenine alleviates neurodegeneration and inflammation in a mouse model of Parkinson’s disease
Submitter: Yota Tatara
LabHead: Taku Ozaki
Description: Imidazole dipeptides (IDPs) have physiological properties, including antioxidant, pH-buffering, and metal ion chelating activities. Carnosine, an IDP, shows promise for treating neurodegenerative diseases, including Parkinson’s disease (PD). However, carnosine-degrading enzymes limit its bioavailability. To overcome this, we focused on balenine, a carnosine analog featuring a methylated imidazole that is resistant to degradation enzymes. In this study, we established a 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine hydrochloride (MPTP)-induced PD mouse model and administered balenine via nasal drops to target the brain via the olfactory epithelium. The MPTP-induced PD mouse model was evaluated through various behavioral tests and biochemical analyses. Proteomic analysis was used to explore the mechanism underlying the neuroprotective effects of balenine.

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