My book on testosterone is now out

[EdF]

Even I am amazed that a mainstream publisher has just published my book "The New Testosterone Treatment" which details how testosterone can be used to fight prostate cancer. After it's publication I came across the following article titled

"Androgen receptor enhances entosis, a non-apoptotic cell death, through modulation of Rho/ROCK pathway in prostate cancer cells." In it the authors conclude: "These results indicated that AR might play a negative
role during PCa progression via influencing entosis by modulating Rho/ROCK pathway."  So the ways that testosterone can kill prostate cancer keeps on mounting. Check out this article at: http://www.ncbi.nlm.nih.gov/m/pubmed/23775364/

Ed Friedman

[Patrick OShea]

Good luck with the book Ed - I just ordered a copy.  -Patrick

 

Dx04 @ 56 (DRE nodule 2002) |bPSA 3.3 (0.8 when nodule found)| GS=4+3, RP - no LN, no SV, but PSA nadir-0.3. DT=3 months Salvage RT 2005. Again, nadir=0.3. No HB. Arimidex. AndroDerm.

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From: EdF <e...@math.uchicago.edu>
To: prostatic-dise...@googlegroups.com
Sent: Wednesday, June 26, 2013 11:23 PM
Subject: [PDT:1285] My book on testosterone is now out

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--
Prostate cancer is an exceptionally heterogenous disease. What is good for one man may not be so kind on the next. Be sure to research and test any new supplement or treatment before adopting it - and in any case run it past a medically qualified person for a second opinion.
 
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[dtc]

Patrick and Ed,

The abstract contained the following

Human PCa samples surveys demonstrated that entosis was found only in CRPC but not in BPH and ADPC where AR was less expressed as compared to CRPC.

Does this indicate you would want to increase T and DHT in CRPC
to increase entosis, and decrease them in non CRPC?

Doug

[EdF]

Doug,

CRPC is known to have much more than usual amounts of intracellular androgen receptor (at least while undergoing ADT). For ADPC, you can artificially induce great increases in the amount of intracellular androgen receptor by using finasteride (increase is seen between months 1 and 6 while treatment is occurring), then use high dose T to take advantage of PC's vulnerability to T when it has lots of intracellular androgen receptor. The optimal number of months to cycle through these two protocols has yet to be determined.

Ed Friedman

[dtc]

Ed,

Any doctor who is actually doing this? Leibowitz?

Doug

[EdF]

Doug,

None that I know of, but hopefully that will change now that the book is out. There may be some who are willing to do so if you ask. E.g., I would suspect that Dr. Leibowitz might be willing to try it.

Ed Friedman