Journal / March meeting curation this Thursday
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Anne-Florence Bitbol
Mar 10, 2015, 10:51:44 AM3/10/15
to Prnceton Biophysics Journal Club
Dear all,
Best,
Anne-Flo
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Electrical synapses among cerebellar molecular layer interneurons
Pepe Alcami (Université Paris Descartes)
Even though it has been known for some time that in many mammalian brain areas interneurons are electrically coupled, a quantitative description of the network electrical connectivity and its impact on cellular properties is still lacking. In the cerebellar cortex, anatomical and functional evidence indicates electrical coupling between molecular layer interneurons. An analysis of the capacitive currents obtained under voltage clamp in molecular layer interneurons of juvenile rats or mice reveals slow exponential components which correspond to the capacitive loading of neighboring cells through gap junctions. Capacitive currents are analyzed to extract parameters which are used to describe network connectivity. These parameters are further used to quantify some consequences of the presence of electrical synapses on cell excitability, and to draw a difference in the connectivity of the two molecular interneurons subtypes: basket cells and stellate cells.
Reference: Alcami P, Marty A (2013) Estimating functional connectivity in an electrically-coupled interneuron network. PNAS 110(49): E4798-4807.
Spring schedule:
(Thursdays, Icahn 200, lunch from 12:00, discussion from 12:15)
Mar 12: Journal / March meeting curation
Apr 2: Journal curation
Apr 9: Gavin Crooks - TBC
Apr 16: Gavin Crooks - TBC
Apr 23 and after: open
This Thursday, we will have a Journal / March meeting curation session.
Everybody gets to discuss shortly a paper or a March meeting talk of their choice.
Next week, we will have a lunch seminar by Pepe Alcami, entitled "Electrical synapses among cerebellar molecular layer interneurons". The abstract is below.
Lunch will be served at 12:00 and the talk will start at 12:15 in Icahn 200.
Everybody gets to discuss shortly a paper or a March meeting talk of their choice.
Next week, we will have a lunch seminar by Pepe Alcami, entitled "Electrical synapses among cerebellar molecular layer interneurons". The abstract is below.
Lunch will be served at 12:00 and the talk will start at 12:15 in Icahn 200.
Open Journal Club slots are available in April / May. Please email me if you would like to lead a discussion then.
*********************
Electrical synapses among cerebellar molecular layer interneurons
Pepe Alcami (Université Paris Descartes)
Even though it has been known for some time that in many mammalian brain areas interneurons are electrically coupled, a quantitative description of the network electrical connectivity and its impact on cellular properties is still lacking. In the cerebellar cortex, anatomical and functional evidence indicates electrical coupling between molecular layer interneurons. An analysis of the capacitive currents obtained under voltage clamp in molecular layer interneurons of juvenile rats or mice reveals slow exponential components which correspond to the capacitive loading of neighboring cells through gap junctions. Capacitive currents are analyzed to extract parameters which are used to describe network connectivity. These parameters are further used to quantify some consequences of the presence of electrical synapses on cell excitability, and to draw a difference in the connectivity of the two molecular interneurons subtypes: basket cells and stellate cells.
Reference: Alcami P, Marty A (2013) Estimating functional connectivity in an electrically-coupled interneuron network. PNAS 110(49): E4798-4807.
*********************
Spring schedule:
(Thursdays, Icahn 200, lunch from 12:00, discussion from 12:15)
Mar 12: Journal / March meeting curation
Mar 19: Talk by Pepe Alcami
Mar 26: Thomas Gregor (+discussion)Apr 2: Journal curation
Apr 9: Gavin Crooks - TBC
Apr 16: Gavin Crooks - TBC
Apr 23 and after: open
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