P-Values or Adjusted P-Values

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Maciel Rodriguez

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Apr 16, 2024, 7:51:49 PM4/16/24
to PrediXcan/MetaXcan
Hi!
First of all, I wanted to thank you for this wonderful tool! 
It's really helping me a lot with my data :) 

I wanted to ask about the P-Values in the output of S-PrediXcan. 
Are these P-values already adjusted (with bonferroni or BH method) and are ready to be used or I still need to adjust them using one od those methods (bonferroni or BH method)?

I wanted to check just in case. In my first output of S-PrediXcan, I get ~ 100 genes with significant P-Values. But after adjusting the P-Value using the BH method, I'm only left with 1 gene with a significant P-Value. I know that this can be a pretty valid result. I just wanted to check if perhaps I didn't need to adjust the P-Values (if perhaps they were already adjusted).

Thanks a lot in advance for your help!

Kind regards!
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