PrediXcan/MetaXcan sQTL results

[Connor Barnhill]

Hello,

We've successfully run the S-PrediXcan and S-MultiXcan methods on our GWAS data using the MASHR sQTL models and have the outputs. My question is, how do I interpret and/or follow up on the results? I see a handful of intron IDs that look significant and I find the relevant single tissue results for those intron IDs. How should I interpret the z-score? Does a negative z-score for an intron imply that a decrease in the excision of that intron leads to an increase in the GWAS trait? How can I recover the SNPs that are predicted to lead to a decrease in the excision of that intron?

Thank you,

Connor

[haky]

Here is the mapping from intron ids to gtex. Also responses to your other questions. https://predictdb.org/post/2023/02/22/how-to-map-introns-to-genes/

I hope this helps

Haky

[Connor Barnhill]

Thank you for the quick response. I will follow these instructions.

Best,

Connor