Phylogenetic Study - Vaccine

[Veronica Koay]

Hi,

Vaccine strain selected based on the similarity with the virus strain
that attacked right? Could we select the virus strain based on the
phylogenetic relationship to get the closely related strain as vaccine
strain? Only closely related virus could stimulate the relevant
antibody production right?

Please correct me if I'm wrong.

Thank you.

Regards,
Veronica

[shankar chatterjee]

hope by this time U got the answer, if not can write back directly to shanka...@gmail.com

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[Veronica Koay]

What is the first step for epitope analysis?

Epitope is the place to trigger antibody production right? Will point mutation affect the antibody production?

Thanks

On Mon, Jun 20, 2011 at 8:44 PM, Veronica Koay <veroni...@gmail.com> wrote:

Hi, I havnt get any answer from this forum yet :(

[Shet]

Hi Veronica,

You are right, epitope is the part of antigen where antibody binds.

In an epitope not only the sequence but also the side chain of the amino acids are important.
If the point mutation changes the amino acid in the sequence of epitope, this may or may
not affect the antibody response depending upon the resultant amino acid.

If you have phylogenetically similar kind of virus still it will be better if you can compare the repertoire
of potential epitopes on viral proteins. Following website will be of great use for you

http://imtech.res.in/raghava/im.html

Also find a latest article on epitope prediction from this group.

http://www.immunome-research.com/content/6/1/6 

Best wishes

shet

Shet Masih, Ph.D
Post Doctoral Researcher
Department of Microbiology & Immunology
Drexel Institute for Biotechnology & Virology Research
Drexel University College of Medicine
PA, USA

[Veronica Koay]

Dear Dr. Shet,

Thank you for your email.

I have few more questions.

Is the antibody that triggered by the vaccine strain bind at the same site as those antiviral drug? 

For influenza case, antibody produced is for hemaglutinin only? or BOTH hemaglutinin (HA) and neuraminidase (NA)? In vaccine compositional design, the vaccine strain is the live attenuated virus right? which means the virus whole genome is contained in the vaccine? therefore can trigger HA anitbody and also NA antibody?

How effective is the current vaccination? Why do vaccinated people will still infected with flu disease, like seasonal flu? How likely if people already get vaccinated still getting the flu? 

Do people really want to take live attenuated virus? Any risk?

When virus keep evolving, how effective is the vaccine? Is vaccine or antiviral drug more effective in combating the disease?

Hope to hear from you. Appreciate lots!

Veronica