I've looked, and I don't see any recent discussions regarding using Closure-compiler with Polymer. I've also looked through the unit tests for the PolymerPass in the compiler - which does provide a few more clues.
Basically I'd like to see documentation on manually creating classes with full type safety, renaming and obfuscation.
Full disclosure - I'm a long time committer to the closure-compiler project so am extremely familiar with the challenges associated with ADVANCED_OPTIMIZATIONS on a project.
Basically before I dive into working with wiring together some of the tools, I wanted to get a recap of the compatibility as it exists now.
Chad Killingsworth