I also have the Elan Cybra, and have no trouble with it under Linux, in either Stentura or TXBolt mode.
Note that the serial port for me is USB0 or USB1 but it doesn't appear until I plug the cord in to the computer.
I have had a couple of working cables "go bad" on me though. Usually wiggling the wire in the connector on one end or the other is enough to fix it for awhile, but the cords do seem temperamental.
Oh and I have to be sure I'm in the group that owns the USB connection (plugdev on Linux), perhaps there's something similar on Mac?
But if you're using the same cable that works on another machine, I don't think any of these could be the issue.
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Be aware also that not all serial to USB cables will work either. I think it has to do with the chipset they use. I've been lucky with the ones I've ordered online so far, but others have reported problems.