Understanding the .diff file of plink1.9

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Wenbin Mei

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Aug 26, 2025, 11:19:09 AM (10 days ago) Aug 26
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Hi!
I have a very basic question on comparing overlapping samples and variants between two filesets. I ran:

plink --bfile file1 \
       --bmerge file2 \
       --merge-mode 6 \
       --out strand_check

Here are the first few lines of strand_check.diff
                SNP                  FID           IID      NEW      OLD
        1:888659:T:C            fid1        iid1      T/T      0/0
        1:888659:T:C            fid1         iid2      T/T      0/0
        1:888659:T:C            fid1         iid3      T/T      0/0
        1:888659:T:C            fid1         iid4      T/T      0/0
        1:888659:T:C            fid1         iid5      T/T      0/0 
It appears that the genotypes are concordant but the coding is different: file1 is number-coded while file2 is letter-coded. Do you know what could have caused this? Aren't all the genotypes in .bed binary (so number-coded)? Is there any way to convert the genotypes to number-coded (0/0, 0/1, 1/1, ./.)?
Thanks a lot!

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