PLINK2 workflow: NA filling vs filtering order

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soogi

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Apr 21, 2026, 10:34:46 PM (5 days ago) Apr 21
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Hi,

When a bfile is created directly from a BGEN file, some genotype calls can become NA. To address this, PLINK2 provides the fill-missing-from-dosage option to recover missing values using dosage information. 

However, I would like to confirm the correct workflow: is it better to fill NA values first and then apply MAF filtering, or to perform filtering before filling NA values?

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